Foreign Market Entry of NAVERTICA, Plc.

Tato diplomová práce se zabývá analýzou vstupu firmy NAVERTICA,a.s. na Jihoafrický trh. Práce obsahuje analýzu společnosti a současné situace na trhu v Jižní Africe. Je aplikována kritická analýza literatury na dané téma společně s analytickými metodami. Opodstatněná doporučení, zda-li vstoupit na cizí trh a jakou formu vstupu zvolit, jsou dána. Tato doporučení jsou založena na vyhodnocení výsledků analýz této diplomové práce.This thesis deals with an analysis of foreign market entry into South Africa and it is focused on company NAVERTICA, PLC. The thesis contains analysis of the company as well as the analysis of the current business environment in South Africa. The literature on this topic is critically reviewed and analytical methods are consequently applied. Justified recommendations to the company, whether to enter the market or not and what form to choose, are given based on the evaluation of findings in this thesis.

Evidence of resonant surface wave excitation in the relativistic regime through measurements of proton acceleration from grating targets

The interaction of laser pulses with thin grating targets, having a periodic groove at the irradiated surface, has been experimentally investigated. Ultrahigh contrast ($\sim 10^{12}$) pulses allowed to demonstrate an enhanced laser-target coupling for the first time in the relativistic regime of ultra-high intensity >10^{19} \mbox{W/cm}^{2}. A maximum increase by a factor of 2.5 of the cut-off energy of protons produced by Target Normal Sheath Acceleration has been observed with respect to plane targets, around the incidence angle expected for resonant excitation of surface waves. A significant enhancement is also observed for small angles of incidence, out of resonance.Comment: 5 pages, 5 figures, 2nd version implements final correction

Measurements of projectile fragments from 70 Zn (15 MeV/nucleon) + 64 Ni collisions with the MAGNEX spectrometer at INFN-LNS

The present work is focused on our efforts to produce and identify neutron-richrare isotopes from peripheral reactions below the Fermi energy. High-quality experimental data were obtained from a recent experiment with the MAGNEX spectrometer at INFN-LNS in Catania, Italy. The main goal of this effort is to describe the adopted identification techniques used to analyze the data from the reaction 70 Zn (15 MeV/nucleon) + 64 Ni. The particle identification procedure is based on a novel approach that involves the reconstruction of both the atomic number Z and the ionic charge q of the ions, followed by the identification of themass. Our method was successfully applied to identify neutron-rich ejectiles from multinucleon transfer in the above reaction 70 Zn + 64 Ni at 15 MeV/nucleon. The analysis of the data is ongoing. We expect to obtain the angular and momentum distributions of the fragments, along with their production cross sections. These data, along with comparisons with theoretical models are expected to contribute to a better understanding of the complex reaction mechanisms of multinucleon transfer that dominate this energy regime

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity among 675 PFA ependymomas. Two major subgroups, PFA-1 and PFA-2, and nine minor subtypes were discovered. Transcriptome profiling suggested a distinct histogenesis for PFA-1 and PFA-2, but their clinical parameters were similar. In contrast, PFA subtypes differed with respect to age at diagnosis, gender ratio, outcome, and frequencies of genetic alterations. One subtype, PFA-1c, was enriched for 1q gain and had a relatively poor outcome, while patients with PFA-2c ependymomas showed an overall survival at 5 years of > 90%. Unlike other ependymomas, PFA-2c tumors express high levels of OTX2, a potential biomarker for this ependymoma subtype with a good prognosis. We also discovered recurrent mutations among PFA ependymomas. H3 K27M mutations were present in 4.2%, occurring only in PFA-1 tumors, and missense mutations in an uncharacterized gene, CXorf67, were found in 9.4% of PFA ependymomas, but not in other groups. We detected high levels of wildtype or mutant CXorf67 expression in all PFA subtypes except PFA-1f, which is enriched for H3 K27M mutations. PFA ependymomas are characterized by lack of H3 K27 trimethylation (H3 K27-me3), and we tested the hypothesis that CXorf67 binds to PRC2 and can modulate levels of H3 K27-me3. Immunoprecipitation/mass spectrometry detected EZH2, SUZ12, and EED, core components of the PRC2 complex, bound to CXorf67 in the Daoy cell line, which shows high levels of CXorf67 and no expression of H3 K27-me3. Enforced reduction of CXorf67 in Daoy cells restored H3 K27-me3 levels, while enforced expression of CXorf67 in HEK293T and neural stem cells reduced H3 K27-me3 levels. Our data suggest that heterogeneity among PFA ependymomas could have clinicopathologic utility and that CXorf67 may have a functional role in these tumors

Modelování dopravního procesu unárním kódem

Analogy of random intervals between two transport units and words of unary binary code is analyzed. This way, article is pointing to questions, which are common for transport theory and theory of information, which allows usage of theory of information results in tranport. These are not only questions of quantification of assortness (entrophy) of transport stream, but also better specification of term capacity of transport system. Properties of random intervals with maximum entropy under minimum length are presented.Článek analyzuje analogii náhodných intervalů mezi dvěmi jednotkami v dopravním proudu a slovy unárního kódu. Tím poukazuje na otázky, které jsou společné pro teorii dopravy a teorii informací, což umožňuje požít výsledky teorii informací v dopravě. Nejsou to jenom otázky kvantifikace neuspořádanosti (entropie) dopravního toku, ale rovněž precizování pojmu kapacity dopravního systému. Podrobněji jsou prezentovány vlastnosti náhodných intervalů s maximální entropií při minimální střední délce